Re:combinatie diverse medicijnen/grapefruit

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Eating grapefruit can work against several prescription medications


Published: Sunday, November 16, 2008

Eating grapefruit in Florida seem to be a statewide activity. Grapefruit is a very healthy addition to a well-balanced diet. Everyone knows that it is rich in Vitamin C, it is low in calories and has a lot of fiber and potassium.

Grapefruit is a unique fruit that has certain characteristics that can change medication absorption and metabolism. In some, consuming grapefruit can have a persistent action on certain medications for up to 72 hours. This very action can cause the usual doses of certain medications to increase and in other medications to decrease.

[i]Anti-arrythmics[/i] can be influenced by grapefruit. The one that is most influenced is the medication Cordarone (Amiodarone). In that same class is Quinidine. Grapefruit increases the blood levels of this medication. When this occurs, it can cause significant changes in the heart.

Medications known as [i]calcium channel blockers[/i] include Plendil, Cardene and Procardia. These are medications that are used in blood pressure and heart conditions. Grapefruit will increase the levels of these medications and can even cause swelling, headache, fast heart rate and in some, a heart attack.

[i]Statins[/i] are medications used for lowering cholesterol. Grapefruit can influence Lipitor, Mevacor and Zocor. Grapefruit will cause these levels to be increased. When this occurs, it causes more muscle aches, irritation, and liver failure.

[i]Cancer medications[/i] include Sandimmune, Tacrolimus and Fortovase. Grapefruit will increase these blood levels and can cause toxicity.

It is a good idea to talk to a doctor before eating grapefruit to find out if it is safe for consumption.

Dr. Gordon J. Rafool is a specialist in family practice and geriatrics at Gessler Clinic in Winter Haven.