default-header

Re:Coronair spasmen door magnesium gebrek

Home Forums Angina pectoris Coronair spasmen door magnesium gebrek Re:Coronair spasmen door magnesium gebrek

#83375
Lisa
Deelnemer

Een studie uit 2000:
http://www.chestjournal.org/content/118/6/1690.full.html

Woord vooraf:
het magnesium gehalte in deze studie werd bepaald IN de erythrocyten (rode bloedcellen), dus niet in het (bloed)serum, wat in onze labs normaal alleen gebeurt.
Die magnesiumbepaling (de standaard serum-test hier bij ons dus) zegt niets over hoe het gesteld is met het intracellulair magnesium gehalte, waar dus een gebrek kan bestaan, wat dan niet wordt ontdekt.
Magnesium is hoofdzakelijk een intracellulair mineraal, en daarom moet het eigenlijk altijd ook IN de cellen gemeten worden..

Een paar stuksjes tekst uit de studie:

The Preventive Effect of Magnesium on Coronary Spasm in Patients With Vasospastic Angina (= prinzmetal angina)

Study: From the First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan.

Study objectives:
Previous studies have reported that magnesium (Mg) deficiency is associated with coronary spasm. However, little is known about the preventive effect of Mg on coronary spasm. The present study investigated whether Mg prevents coronary spasm in patients with vasospastic angina (VSA).

Design: Effectiveness trial.

Setting: University medical center.

[skip]

Magnesium (Mg) deficiency has also been considered as a possible factor contributing to the genesis of coronary spasm.
Furthermore, it has been reported that infusion of Mg reduced coronary spasm attacks in patients with VSA.
However, no report has verified the [i]preventive effect of Mg on coronary spasm [/i] using quantitative coronary angiography (QCA). Therefore, we investigated the changes in the diameter of coronary arteries at baseline and during acetylcholine (Ach)-induced coronary spasm in patients with VSA using QCA before and after infusion of Mg.

[skip]

Conclusion
Mg infusion causes nonsite-specific dilation of the coronary arteries and suppresses Ach-induced coronary spasm in patients with VSA. These findings suggest that IV Mg infusion may have therapeutic application in modulating the increased coronary tonus in patients with ischemic heart disease associated with coronary spasm.
Furthermore, these results suggest that long-term oral Mg supplementation might prevent or reduce coronary spasm in patients with VSA.